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In addition to neurotrophic and protective actions in dopaminergic neuronrich brain regions and attenuation of locomotor dysfunction, amelioration of L-DOPAinduced dyskinesia has been reported across PD rodent models (161, 162)

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For patients experiencing significant symptoms, temporarily pausing therapy, maintaining the current dose for an additional 2-4 weeks before advancing, or implementing smaller dose increments when formulation allows, may improve tolerance

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Diabetes, Obesity & Metabolism, 27(6), 35233525

The IDH3 isoform is involved in the TCA cycle where it oxidatively decarboxylates isocitrate to 2-oxoglutarate (-ketoglutarate)