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The interaction between S100A2 and KPNA2 mediates NFYA nuclear import and is a novel therapeutic target for colorectal cancer metastasis

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In yeast, nutrient-responsive phosphorylation of PUF protein Puf3p at the N-terminal low complexity region can switch the fate of its target mRNAs from degradation to translation (Lee and Tu, 2015), suggesting a possibility that post-translational modifications can provide an additional layer of regulation that affects PUF protein activity