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(Mechanism) Inhibition of gallbladder contraction GLP-1 inhibits gallbladder contraction reduces bile excretion Biliary stasis Gallstone formation In human studies as well, a decrease in gallbladder ejection fraction was confirmed 5) Rapid weight loss Rapid weight loss has long been associated with increased biliary cholesterol and promotion of gallstone formation
Many patients initiating GLP-1 RA therapy do so without baseline liver staging, reflecting persistent gaps in guideline adoption
[PubMed ID: 39939219]
Addressing these micronutrient gaps can enhance the effectiveness of binder protocols and antioxidant therapies
The more modest increases from 4mg to 8mg to 12mg suggest diminishing returns once the glucagon threshold is crossed
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