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[DOI] [PubMed] [Google Scholar] Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shaded E, Levine M

administered alpha-melittin nanoparticles (-MEL-NPs) and injected intravenously with a concentration of 20 mg/kg which showed the growth inhibition of B16F10 (human melanoma cells) and have no toxic effects on normal cells (209)

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Besides confirming these results, another study run in rats (52-53) showed a significant decrease in pro-angiogenic factors such as VEGF at both serum and peritoneal fluid levels, but also a significant decrease in pro-inflammatory molecules such as MCP-1 in the peritoneal fluid and at the serum level

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