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It is also known to be closely related to the T2MD metabolic syndrome, and the morbidity and mortality of CVDs (183, 184)

doi: 10.3389/fnins.2022.991779

Cryosurgery: A treatment that uses an instrument to freeze and destroy abnormal tissue, such as carcinoma in situ

Nose-only exposure to cigarette smoke resulted in significantly stronger effects than whole-body exposure in terms of epithelial degeneration and ulceration in nasal epithelia, lung inflammation, and it is associated to a higher stress response compared to whole-body mode (Kogel et al., 2021)

Readers are encouraged to read these articles for further background on how ROS are generated during respiration and what defences our body has against them.) More specifically, GPx1 neutralises and protects against damage from one ROS in particular hydrogen peroxide (H2O2)