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Common negative reports include difficulty distinguishing GI side effects from autoimmune flares, insomnia and anxiety during dose adjustments, muscle and body aches that overlap with autoimmune symptoms, and concerns about drug interactions and medication absorption changes

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Clinical trials, such as the STEP program, show that Semaglutide can help people lose up to 15% of their total body weight in about 20 weeks

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Researchers first characterised the peptide in the early 1990s, and its since built up one of the most extensive bodies of preclinical literature in the field

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