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Centrally administered GIP leads to an increase in pro-inflammatory cytokines and factors such as Il-6 and Socs3 in the hypothalamus in mice [230], diminishes the anorectic effects of insulin in the brain and attenuates the impact of leptin, resulting in leptin resistance [231]

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[18] [19] [20] [21] [22] Diseases that disturb the nervous system may lead to constipation, such as diabetes mellitus, autonomic neuropathy, Chagas' disease, and Hirschsprung's disease

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Updated May 19, 2026