glp 1 gut hormone Comparing the anorexigenic effects and mechanisms of gut-derived GLP-1 and its receptor agonists: insights into incretin-based therapies for obesity | Diabetology International GLP-1 for Weight Loss and

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PMID: Summary Keywords biologic therapy, early psoriatic arthritis, GLP-1 receptor agonists, inflammation, metabolic syndrome, psoriasis Citation Ciancio G, Maranini B, Sandri G, Amati G, Bortoluzzi A, Silvagni E, Govoni M and Giuggioli D (2026) Glucagon-like peptide-1 receptor agonists in psoriasis and psoriatic arthritis: emerging evidence and future research opportunities

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One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition