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Therapeutic Indications Beta-Blockers Cardiac Effects Decrease contractility (- inotropy) Decrease relaxation rate (- lusitropy) Decrease heart rate (- chronotropy) Decrease conduction velocity (- dromotropy) Vascular Effects Smooth muscle contraction (mild vasoconstriction) Beta-blockers are used for treating hypertension, angina, myocardial infarction, arrhythmias, and heart failure