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Tretinoin accelerates skin cell turnover, while Niacinamide brightens and evens skin tone

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R Methylation: SAM-dependent methyltransferases catalyze the SN2 transfer of the methyl group from the sulfonium center of SAM-e to an electron-rich acceptor atom (O, N, or S) on the substrate, producing the methylated product and SAH

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Sometimes even longer