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Discard any peptide solutions that appear cloudy, discoloured, or contaminated

Do not wait for routine labs Fever, bloody stool, severe abdominal pain, spreading rash, jaundice, allergic symptoms, or severe wound changes need medical review

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On the other hand, TIS can be induced by anticancer drugs and radiotherapy

For extensive disease, vermilionectomy (surgical resurfacing of the vermilion) is sometimes appropriate this is a specialist plastic surgical procedure For diffuse actinic cheilitis we typically recommend topical field treatment first, with surgical or laser intervention reserved for focal areas or treatment failures

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