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Showed in multiple studies that combining a GHRH analog with a GHRP produces a synergistic (greater than additive) GH response because the two signals converge on somatotrophs through independent intracellular pathways [8]

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Unlike GHRP-2 and GHRP-6, which can elevate cortisol, prolactin, and acetylcholine levels, ipamorelin has been shown in animal studies to have no significant effect on adrenocorticotropic hormone (ACTH), cortisol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), or prolactin release