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Taking extra doses increases the risk of serious adverse events including severe gastrointestinal distress, pancreatitis, and unpredictable blood sugar changes

The repurposing of metformin or TZDs for neuroprotection in AD and PD remains a promising, but not yet conclusively proven, strategy

In addition, it has been debated whether erythrocyte membrane injury could promote the thrombotic complications frequently observed in COVID-19 patients [342], and that reduced deformability of erythrocytes may contribute to inflammation and hypoxia in COVID-19 patients [343]

Results 5FU treatment alters mitochondrial biogenesis and dynamics in cancer cells Treatment with 5FU causes modest cell cycle arrest (Extended Data Fig

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Gpx activity was expressed as units per gram of protein (U/g protein)