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In addition to the lack of functional NNT in C57BL/6J mice (Ronchi et al., 2013), they also lack the stop codon for the NADK2 gene, resulting in a longer, potentially unstable mitochondrial protein (Timmermans and Libert, 2018) that may further contribute to the dysfunctional mitochondrial NADPH generation and antioxidant function

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Each step consumes one molecule of NADPH (biosynthetically derived from vitamin B 3 ) and produces one molecule of NADP

Nutrients, 12(9), 2502