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The strong before and after data is for tesamorelin alone, in HIV patients

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doi:10.1080/07315724.2021.1878967

This means: It is not FDA-approved for human use outside of clinical trials It cannot be sold for dietary or medical use only for research purposes Possessing or using it without a prescription is technically legal in personal research contexts but may violate athletic federation or workplace testing rules Drug Testing Considerations CJC1295 and its metabolites can be detected in anti-doping tests and are listed on the World Anti-Doping Agency (WADA) Prohibited List under Peptide Hormones, Growth Factors, and Related Substances

Remarkably, those on the highest dose of orforglipron achieved an average weight reduction of 12.4%, translating to about 27.3 pounds, compared to only 0.9% weight loss for placebo users

Tirzepatide joined shortly after