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Additionally, approximately 20.9% of retatrutide users at 12 mg experienced dysesthesia (skin sensitivity/tingling), a side effect not seen with tirzepatide

Allergens or toxins in the urine are thought to cause the bladder walls to become sensitized to increased mast cells.[ref][ref][ref] Vulvodynia and mast cell activation: Vulvodynia is a chronic genital pain condition that includes an increased number of mast cells

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Renal effects, including acute kidney injury, have been reported rarely in post-marketing surveillance, typically in the context of severe gastrointestinal adverse effects leading to dehydration

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Glucagon directly affects hepatic lipid metabolism, reducing fat production in the liver and increasing fat export