Farnesoid X receptor (FXR) agonists such as obeticholic acid enhance lipid clearance and bile acid signaling but exhibit time-of-daydependent effects, with greater efficacy when administered at peak FXR expression (24, 131)
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[DOI] [PubMed] [Google Scholar] Oh YC, Kang OH, Kim SB, Mun SH, Park CB, Kim YG, Kim YI, Lee YS, Han SH, Keum JH, Shin DW, Ma JY, Kwon DY
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