While this appetite reduction facilitates caloric restriction, it creates a nutritional challenge: many patients struggle to consume adequate protein despite increased physiological needs during active weight loss
However, in real-world settings, where people are using semaglutide as part of their regular treatment, side effects may not always be reported
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In a 68-week trial involving non-diabetic adults with overweight or obesity, the efficacy and safety of weekly subcutaneous semaglutide (2.4mg) and once-daily subcutaneous liraglutide (3.0mg) were compared [10]
Gallbladder issuesincluding gallstones and inflammationhave also been documented at higher rates in clinical trials compared to placebo
[11] [16] Clinical observations suggest that semaglutide may improve liver enzyme levels in many patients, particularly those with metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alcoholic fatty liver disease or NAFLD)