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LR3 binds IGF1R with affinity comparable to native IGF-1, with reported Kd values in the sub-nanomolar to low nanomolar range across multiple published cell line studies

Human pancreatic islets were isolated via collagenase digestion and purified from four non-diabetic human donors (Supplementary Table S1) as described previously 44

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Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice