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Common biological features of chronic injury Microvascular limitation: the tissue is under-perfused, which slows nutrient delivery and waste removal Inflammatory persistence: cytokine signaling stays elevated and disrupts remodeling Disorganized collagen: collagen exists, but it is poorly aligned, weak, or prone to reinjury Mechanical mismatch: loads exceed tissue capacity due to weakness, compensation, or instability Neurogenic sensitivity: irritated tissues and nerves amplify pain signals even when imaging is normal In other words, chronic injuries do not usually need one intervention
But if you think you can inject it weekly and keep eating like garbage while sitting on the couch, youre in for a rude awakening
The primary endpoint was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke (three-component major adverse cardiovascular events [MACE-3])
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Tina, some of your appointments can be scheduled as a telephone consultation