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But these data gaps further underscore the need to study this population, as currently, there is "limited or no clinical guidance" on the use of GLP-1s prior to conception, the commentary authors wrote

For the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R), a mean slope of 1.0 was observed in the treated group compared to 1.4 in the untreated patients ( p = 0.0575)

In particular, free fatty acids and SCFAs play significant roles in the microbiota-host lipid metabolism axis, which has important implications for human health [60, 61]

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