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Because retatrutide has not yet received approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), its full safety profile is still being established through ongoing clinical trials

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HoloTC concentrations followed a similar trend, with the loading dose regimen reaching a median of 300 pmol/L initially, then decreasing to 184 pmol/L at 90 days

This is not a reason to treat CJC-1295 as safer and this is the crucial point because CJC-1295s apparent lack of documented adverse effects reflects the absence of long-term study , not a demonstration of safety