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IGF-1 LR3 Administration Notes Researchers should note that studies conducted specifically on IGF-1 LR3 are limited

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Acknowledgements We thank Colleen McHugh and Harriet Pratley for the generation of GspD/PilQ antisera, Jos Muoz-Dorado for providing plasmids for copper-inducible gene expression, Tm Mignot, Emilia Mauriello, and Penelope Higgs for providing carbohydrate deletion strains, Daniel Bollschweiler, Florian Beck, and Harald Engelhardt (MPI of Biochemistry, Martinsried) for their help with averaging the negatively stained A

Global IGF-1R knockout embryos exhibit more severe skeletal defects than igf-1 null animals and die shortly after death, suggesting that both IGF-1 and IGF-2 acting via their shared receptor are involved in regulating skeletal development in the embryonic stage

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