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The peptide's upregulation of VEGFR2 at both mRNA and protein levels sensitizes healing tissues to angiogenic signals while its activation of the Src-Caveolin-1-eNOS pathway generates nitric oxide essential for vascular development and tissue perfusion

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Likewise, due to the large presence in human fetuses and adult tissues (in situ hybridization and immunostaining) [14], the concept holds a regulatory physiologic role in bodily functions [14], also based on similar beneficial effects in other species (i.e., birds [73] and insects [74,75,76])

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