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If your symptoms last longer than a few weeks, or if you notice blood in your stool, strong abdominal pain, fever, or unintentional weight loss, contact your healthcare provider

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By staying hydrated, you can: help your body metabolize the semaglutide so its as effective as possible help your kidneys filter waste and byproducts of the medication from your blood maintain your energy and prevent dehydration help prevent or ease constipation or digestive distress Side effects of semaglutide weight loss drugs Studies have shown that most people taking semaglutide drugs have mild-to-moderate side effects, mostly around gastrointestinal upset or nausea ( see: Mayo Clinic and Nature)

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[1] Pharmacokinetic modeling with modern LC-MS/MS assays shows that intranasal delivery produces highly variable but measurable plasma exposure, with peak levels in 15-45 minutes and an apparent half-life of roughly 30 minutes, suggesting rapid systemic clearance and emphasizing the importance of titrating dose to symptom window