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observed similar ultrastructural changes in the rats kidney after MTX treatment, and they attributed these alterations to the direct toxic effects of MTX metabolites that affect membrane permeability

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Retrieved from Hernandez, I., San-Juan-Rodriguez, A., Good, C

PubMed , Antioxidants & Redox Signaling , vol

The peaks corresponded with metabolites in several pathways including GSH metabolism, purine metabolism, pyruvate metabolism, propanoate metabolism, TCA cycle, galactose metabolism, starch and sucrose metabolism, nicotinate and nicotinamide metabolism, cysteine and methionine metabolism, and arginine and proline metabolism