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Formononetin treatment dose-dependently reduced mast cell degranulation, histamine release, and inflammatory cytokine expression in RBL-2H3 cells and mouse bone marrow derived mast cells, reducing IgE-induced MAPK and NF-B expression in vitro [122]

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It's actually a little more complicated because for instance, carbohydrates stimulate insulin secretion, protein stimulates insulin secretion, but it also stimulates growth hormone secretion

10.3390/molecules21040399 55 MansouriM

Garoufalia Z, et al