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Similar to other antioxidants, NAC may exhibit pro-oxidant actions, but these are generally limited to higher doses of 5501500 mg/kg/day [117,118,119]

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Berberrubine, a main BBR metabolite, alleviates NAFLD by reducing CD36 expression Moreover, berberine maintains glucose homeostasis in HFD-fed mice by upregulating glucose transporter 2 (GLUT-2) and glycogen synthase kinase 3 (GSK3) protein expression and inhibiting glucose 6 phosphatase (G6Pase) protein expression (Yang et al., 2022c)

Such studies may facilitate the identification of novel therapeutic targets and the development of innovative treatment options

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