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A 2023 analysis of the SUSTAIN and PIONEER trials published in Cardiovascular Diabetology showed significant reductions in high-sensitivity C-reactive protein, a marker of systemic inflammation, among patients taking semaglutide

For research protocols, administration is often done on an empty stomach, either in the morning or before bed

Sold as Mounjaro (for diabetes) and Zepbound (for weight management), tirzepatide has quickly become the most prescribed alternative for people who want more weight loss than semaglutide delivers

Given the substantial cost burden on plan sponsors, it will be crucial to see how effective these programs are at improving long-term cardiometabolic health and reducing downstream complications, justifying the investment and potentially sustaining coverage

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