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In a surgically induced-OA model in rats, liraglutide also attenuated rat cartilage degeneration through suppressing the release of inflammatory mediators and protected chondrocytes against endoplasmic reticulum (ER) stress and apoptosis induced by interleukin-1 (IL-1) or triglycerides [46]

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Additionally, they are termed immunoregulatory cells for their ability to produce cytokines/chemokines that shape B/T cell responses and influence DC/macrophage/neutrophil functions, reflecting the complex biological network underlying their functions and supporting their value in immunotherapy (113, 114)

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