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Alpha-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome

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The anti-apoptotic effect was attenuated by PKA inhibition or GLP-1-R knockdown, confirming its dependence on GLP-1-R-PKA/-catenin signaling

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showed significant binding to ER receptor (the value of KD were 118 nM and 85 nM respectively) (Zhao et al., 2016) (Figure 2)