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10.1016/j.biopha.2021.112122 51 GinsbergH

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2 Mechanisms of lipedema disease progression Lipedema is a chronic disorder of the loose connective tissue characterized by pathological expansion of subcutaneous adipose tissue

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Mol Neurobiol 54:36523664 Xifro X, Vidal-Sancho L, Boadas-Vaello P, Turrado C, Alberch J, Puig T, Verdu E (2015) Novel epigallocatechin-3-gallate (EGCG) derivative as a new therapeutic strategy for reducing neuropathic pain after chronic constriction nerve injury in mice

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In another study evaluating the potential of Pinoresinol-4- O --d-glucopyranoside (Pgu) using the lithium/pilocarpine-induced rat model, seizure induction caused an increase in the levels of malondialdehyde (MDA) a marker of oxidative lipid damageand decreased catalase activity, while also increasing the expression levels of PTGS2, all of which was reversed by Pgu pretreatment, which also mitigated neurodegeneration 47

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