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Yerba mate does not produce, contain, or stimulate endogenous GLP-1 release in any meaningful way
Support glutathione and redox balance Address oxidative stress to stabilize inflammatory signaling
Three trials that compared ALCAR treatment (1-3 g/day for 7-12 weeks) and antidepressant medications found ALCAR was as effective as antidepressants in treating depressive symptoms (95)
Anything, it seems, to get a drug or compound past the blood brain barrier to the heart of the problem
Importantly, weight-matching through calorie restriction or pair-feeding to lean control body weights does not restore leptin signaling in these other BBS models, resulting in persistent hyperleptinemia and increased fat mass (24, 26)
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