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J Pharm Sci (2013) 16:20716

Khurana, J.A

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10.1007/s10787-017-0323-6 76 MihovilI.RadicB.BrcicL.BrcicI.VukojaI.IlicS.et al (2009)

However, the latter are unlikely to affect interpretation of the main conclusions, as administration of metformin by the enteral route has been shown to be more effective for glucose-lowering than intravenous or intraportal administration [5], and pharmacological inhibition of renal excretion of metformin, thereby augmenting plasma metformin concentrations, has little impact on blood glucose [41]

What are the main side effects of this combination therapy