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Among the 106 participants who completed follow-up: Mean body weight decreased approximately 10% at seven months and 13% at 12 months

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This promotes relaxation of the diaphragm

Gastroesophageal Reflux : Delayed gastric emptying, a therapeutic mechanism of tirzepatide, may paradoxically worsen gastroesophageal reflux disease (GERD) in susceptible individuals

This indicates that the benefits of retatrutide extend beyond weight loss to include significant improvements in metabolic health