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The authors noted that body weight had not appeared to plateau by week 48 in the highest-dose group and characterized this as warranting evaluation in longer-duration studies

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Increased preosteoblast adhesion and osteogenic gene expression on TiO2 nanotubes modified with KRSR

If gastrointestinal symptoms are severe or persistent, delaying dose escalation or temporarily reducing the dose may be appropriate, as guided by the prescribing healthcare provider

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Once the top d 9 -TMAproducing community was identified, the cells were spread and plated