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All of these happen after 6 PM for the majority of the population

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Mild fluid retention may be manageable with dietary changes (reducing sodium intake) and tracking

"Efficacy and tolerability of tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes: A 12-week, randomized, double-blind, placebo-controlled study to evaluate different dose-escalation regimens"