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Clinical trials demonstrated average weight reductions of 15-21% of body weight over 72 weeks in people with obesity (SURMOUNT-1), while more modest weight loss was observed in type 2 diabetes patients (SURPASS trials)

SLC uptake systems, including OATs/OATPs, participate in inter-organ handling of GSH conjugates and precursors, influencing tissue GSH balance and drug disposition

P.ThelenN.RenauldJ.et al (2015)

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After several weeks of training for all study-related procedures, 70 out of 85 monkeys were selected based on blood chemistry and BW data collected at the end of the training period

Two ubiquitin-like conjugation systems are crucial for vesicle elongation (Mizushima and Komatsu, 2011)