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Constipation is already common in people with an underactive thyroid, and adding a medication that delays gastric emptying can worsen symptoms

Estrogen may play a protective role by mitigating these pathological response mechanisms (Figure 3)

You're missing the transport mechanism

Tingling or numbness: Pins and needles or numbness in the hands, feet, or legs

We found an indirect effect of GLP-1RAs on SA through BMI(OR 0.86 [95%CI 0.751.00], P = 4.56 10 2 ), with a mediation proportion of 20.28% (95% CI [0.3740.16%]),and through current tobacco smoking (OR 0.95 [95%CI 0.910.99], P = 2.75 10 2 ), with a mediation proportion of 6.65% (95%CI [0.74%12.57%]).The mediating effect of alcohol consumption was not observed (P = 1.29 10 1 ) (Fig

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