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It says combination therapy increases the frequency of required lab monitoring, with a baseline metabolic panel, liver enzymes, lipids, and glucose checked every four to six weeks initially

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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Dawson RT, Harrison MW

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To counter these threats, cells have evolved molecular chaperones that mitigate the toxic effects of such proteins by preferentially binding to exposed hydrophobic regions, thereby facilitating their refolding or targeting them for degradation 62,94