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Downregulation traditionally refers to a reduced number of functional receptors present in cells, usually detected by reduced B max in radioligand-binding assays of tissue extracts, which occurs as a result of enhanced degradation and/or reduced biosynthesis of receptors (Tsao and von Zastrow, 2000)

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The reviewed studies also noted increased production of decorin, a proteoglycan that plays a role in collagen formation and wound healing

Research published through the National Library of Medicine has explored its role in tissue repair and inflammation modulation

Becke AD (1993) Density-functional thermochemistry