Additionally, in microglia, LRRK2 exerts a negative regulatory effect on -syn clearance by downregulating the early endocytosis pathway, as LRRK2 -knockout microglia exhibit enhanced -syn uptake and clearance associated with increased Rab5-positive early endosomes and improved Rab5-dynamin 1 coordination (195)
It is completely valid to feel overwhelmed by the sheer effort required to simply exist on high-symptom days
Tranexamic Acid: Known for its effective skin brightening properties, it helps to reduce pigmentation, even skin tone, and prevent the formation of dark spots
CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing
Please note that this information should not be treated as a replacement for physical medical consultation or advice
Antibody-stained protein signal was amplified and visualized using SuperSignal West Pico PLUS chemiluminescent substrate (Thermo Fisher #34578) and imaged with a ChemiDoc MP Imaging system (Bio-Rad)