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Diabetologia 56 (5), 98594

Nephron J

Clinical trials have utilized doses ranging from 1 mg per day up to 30 mg per day in divided doses for various administration routes, demonstrating safety across a wide dose spectrum

However, this aspect of its action is potentially problematic in PWS, since many individuals with PWS already have decreased stomach emptying rates and generally slow GI transit (which does not seem to reduce their appetite)