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At this performance-focused tier, doses of 5-10 mg before training sessions, three to five times per week, represent the upper range of current clinical practice [2]

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AOD-9604 completed six human trials enrolling more than 900 participants between the late 1990s and 2007

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A consultation is especially important if you: Have a known allergy to B vitamins or any of the MIC components Are pregnant, breastfeeding, or trying to conceive Have kidney disease, liver disease, or a history of kidney stones (methionine metabolism can affect uric acid and homocysteine levels) Take blood thinners, immunosuppressants, or medications that interact with B12 absorption (such as metformin) Have a sulfa allergy (methionine is a sulfur-containing amino acid) Have a trimethylaminuria (fish-odor syndrome) diagnosis, which affects choline metabolism Have a history of cardiovascular events or uncontrolled hypertension This list is not exhaustive, and it is not a substitute for an individualized assessment

Mayo Clinic - Vitamin B12 deficiency anemia National Institutes of Health (NIH) - Vitamin B12 Fact Sheet for Health Professionals Harvard Health Publishing - Vitamin B12 deficiency: What to know NHS (National Health Service) - Vitamin B12 or folate deficiency anemia American Academy of Family Physicians - Diagnosis and Treatment of Vitamin B12 Deficiency