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5 With prandial insulin (AWARD-2) Patients were randomised to dulaglutide once weekly or insulin glargine once daily, both in combination with prandial insulin lispro three times daily, with or without metformin

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The SURPASS clinical trial program did not identify increased cardiovascular events with tirzepatide compared to placebo or active comparators, though dedicated cardiovascular outcome trials are still ongoing

B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic -cells

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