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This system regulates extracellular glutamate concentrations through non-vesicular release, establishing a vital feedback loop: the released glutamate activates presynaptic group II metabotropic receptors (mGluR2/3), which in turn inhibit vesicular glutamate release and offer protection against N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity (Figure 2) [8,69,70,71]

4.4 Representative evidence base: what has been shown and what remains uncertain Representative studies report improved intracellular delivery and enhanced anticancer effects of MSN-loaded phenolics compared with free compounds, including curcumin-loaded MSNs (Table 1 to improve manuscript usability and to make the translational signal of each study explicit

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16 It was believed that osteoarthritis was simply the result of age-related wear and tear of the joints, as well as the body failing to produce enough cartilage

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