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Trans-physiological barrier delivery: nanoscale carriers overcome limitations of conventional agents in penetrating barriers (e.g., bloodbrain barrier and synovial membrane) through size-dependent diffusion and active targeting moieties (e.g., hyaluronic acid-modified silk fibroin nanoparticles), prolonging drug retention at inflammatory sites (Garhwal et al., 2024)

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Notably, the pharmacological inhibition of GPx reversed all the above-mentioned radioprotective effects of DHS in the irradiated cells

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These are typically mild to moderate and often transient, decreasing over time as the body adjusts to the medication