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For scientists and industry observers, the clinical development of cagrilintide provides valuable insights into amylin biology, receptor pharmacology, and the broader field of peptide-based metabolic research, regardless of the outcome of ongoing regulatory evaluations
Nevertheless, enhanced abundance of DPP4 within adipose tissue of obese subjects may be involved in adipose tissue remodeling and substantially augments the lipolytic activity of enlarged adipocytes ( Moreover, dendritic cells and macrophages resident in visceral adipose depots exhibit an increased DPP4 expression in response to inflammation or in the obese state ( Adipose Tissue as Relevant Source of Circulating DPP4 Serum levels of sDPP4 are altered in many pathophysiologic conditions, including different types of cancer, allergic asthma, or hepatitis C ( Endocrine Effects of Soluble DPP4 Although there is clear evidence that increased circulating levels of sDPP4 are associated with hallmarks of obesity and type diabetes, such as whole-body IR, elevated BMI, and adipocyte hypertrophy, there are only few studies investigating the endocrine effects of sDPP4
COVID-19-Associated dyslipidemia: implications for mechanism of impaired resolution and novel therapeutic approaches
Beer L, Mildner M, Ankersmit HJ
