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J Psychiatr Ment Health Nurs 15:424434 Tardiolo G, Bramanti P, Mazzon E (2018) Overview on the effects of N-Acetylcysteine in neurodegenerative diseases

During dose escalation in the clinical trials, subjects were allowed to remain at a GLP-1 dose for up to 8 wk, as needed, to allow GI side effects to dissipate [14,15]

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At the proteolytic level, GLP-1 RAs may reduce muscle protease activity and modulate inflammatory pathways, thereby attenuating protein breakdown and contributing to muscle mass preservation [39, 84]