semaglutide gout GLP-1 Drugs Could Raise the Risk of Weaker Bones and GLP-1s May Increase Risk Of

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This introduces clinical heterogeneity and considerably attenuates the practical interpretation of pooled estimates, given the well-established beneficial effects of GLP-1 RAs in reducing both HbA 1c and body weight, as opposed to the neutral effect of a placebo intervention [4,5,6]

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Technically yesoff-label prescribing is legalbut most weight loss specialists do not recommend it due to limited efficacy data and compounded cardiovascular risks